Some 60,000 people have descended on the Isle of Wight for the annual music festival, headlined by the Rolling Stones on Sunday evening.
Grammy-nominated band Snow Patrol led the opening night on Friday with a set that included Chocolate and Chasing Cars.
Leicester four-piece Kasabian took to the stage on Saturday night before Muse played.
It was an extra special night for frontman Matt Bellamy who announced it was also his birthday.
Known for their energy and experimentation, their well-produced and entertaining show featured hits such as Knights of Cydonia and an extremely sexy and vocally challenging version of the track Feeling Good, made famous by Nina Simone.
Bellamy wowed the crowd with several piano solos throughout the set, which would certainly have impressed any classical artist.
Perhaps the temperamental screens set up on the side of the stage which allowed fans to see the performers up close were a disappointment to some.
Throughout Muse's performance they flickered off and on. Some fans grew impatient and walked away, unable to see what was going on.
However, the majority were not put off and stayed put right until the end.
'Incredible show'
"The stage show was just incredible. They always put on a massive show for the crowd," said Neil Douthwaite, 22, from Birmingham. 
"Matt communicated really well with the crowd which was good to see as well," he added.
Kasabian so far have been brilliant, Snow Patrol were amazing and Muse were great great great," said Ashley Connor, 22, who travelled for 12 hours from Dublin to get to the festival.
"They are a great live act and the stage show was amazing," she said.
Pam Reason - who said she was "old enough to have been at the 1970 festival" - enjoyed their set too.
Asked what act she had enjoyed the most she said: "If you had asked me that on Saturday morning it would have been Snow Patrol, but it has to be Muse. They were absolutely fantastic."
'Genius'
Matt Bean, 27, agreed: "They were stunning - stunning set, stunning show. I'm glad they headlined as they really were good. 
"Matt is a very talented man, it makes people who are trying to play an instrument not want to bother, because you will never be that good. He is a genius."
But not everyone agreed with the decision to choose Muse over Kasabian for the headlining slot.
Donna Morris - also from Dublin - said: "Kasabian were so much better than Muse. They should have been the headliners."
Matt Francis from Portsmouth added: "Muse were rubbish. Kasabian should have headlined. Muse are skilled musicians but not my cup of tea."
Among the other acts, Amy Winehouse made an appearance in her trademark white vest top and cut-off jeans.
She admitted to the audience that she was drunk - but still managed to put on a stellar performance.
Richard Sharp, from Portsmouth, said he had enjoyed Ash the most as he had "grown up on their music".
But standing in a three hour queue for a cash machine was a definite festival lowlight for him.
Prepared for rain
It was not just the musical acts competing for attention on the island. 
The Red Arrows conducted a 20 minute surprise display, which managed to hold what seemed to be the whole crowd's attention. Everywhere you looked people's eyes were fixed upon the jet planes that soared through the air.
At one point loud gasps could be heard as six jets flew very close overhead - and flying very close together too.
Many festival revellers expected a downpour and came prepared with Wellington boots - but the sun stayed out.
Ariane Turner from the Channel Islands said she was really glad - but declared there was not "enough shelter as it is pretty hot".
For Thomas Powell, 21, from South Yorkshire, it was not just the great weather, talented artists and variety of great food that made the weekend so enjoyable.
"Being with friends rather than the actual shows has been my highlight," he said.
